Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening

Handl, Jiří; Malinak, David; Čapek, Jan; Andrys, Rudolf; Roušarová, Erika; Hauschke, Martina; Brůčková, Lenka; Česla, Petr; Roušar, Tomáš; Musilek, Kamil

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Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening

Handl, Jiří; Malinak, David; Čapek, Jan; Andrys, Rudolf; Roušarová, Erika; Hauschke, Martina; Brůčková, Lenka; Česla, Petr; Roušar, Tomáš; Musilek, Kamil

10.1021/acs.chemrestox.0c00489

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URI: https://hdl.handle.net/10195/79239

Datum publikování: 2021

Typ dokumentu: article

Abstrakt:

Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole-pyridinium product.

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