dc.contributor.author |
Martinková, Pavlína
|
cze |
dc.contributor.author |
Kränková, Barbora
|
cze |
dc.contributor.author |
Šelešovská, Renáta
|
cze |
dc.contributor.author |
Janíková, Lenka
|
cze |
dc.date.accessioned |
2018-02-27T03:04:20Z |
|
dc.date.available |
2018-02-27T03:04:20Z |
|
dc.date.issued |
2017 |
eng |
dc.identifier.isbn |
978-80-7444-052-6 |
eng |
dc.identifier.uri |
https://hdl.handle.net/10195/69999 |
|
dc.description.abstract |
Voltammetric behavior of leucovorin has been investigated for the first time using boron-doped diamond electrode (BDDE) and the method for its determination was developed. Leucovorin provides two well-developed oxidation peaks at about +900 and +1450 mV (pH 5) on BDDE. Britton-Robinson buffer (pH 3.0) was chosen as an optimal supporting electrolyte for its determination using differential pulse voltammetry (DPV) with optimized parameters. Limit of detection 1.5×10−8 mol L−1 was reached for leucovorin determination and linear dynamic range 1.5×10−7-2.5×10−5 M was obtained. Relative standard deviation of repeated measurements (RSDM(11) = 0.7 %) and relative standard deviations of repeated determinations (RSDD(5) < 3.0 %) were calculated to confirm very good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation. |
eng |
dc.format |
p. 210-215 |
eng |
dc.language.iso |
eng |
eng |
dc.publisher |
Univerzita Karlova. Přírodovědecká fakulta |
eng |
dc.relation.ispartof |
13th ISC Modern Analytical Chemistry |
eng |
dc.rights |
open access |
eng |
dc.subject |
Leucovorin |
eng |
dc.subject |
Oxidation |
eng |
dc.subject |
Boron-doped diamond electrode |
eng |
dc.subject |
Differential pulse voltammetry |
eng |
dc.subject |
Leukovorin |
cze |
dc.subject |
Oxidace |
cze |
dc.subject |
borem dopovaná diamantová elektroda |
cze |
dc.subject |
diferenční pulzní voltametrie |
cze |
dc.title |
Voltammetric determination of leucovorin in pharmaceutical samples |
eng |
dc.title.alternative |
Voltametrické stanovení leukovorinu ve farmaceutických přípravcích |
cze |
dc.type |
ConferenceObject |
eng |
dc.description.abstract-translated |
Voltametrické chování leukovorinu bylo studováno na borem dopované diamantové elektrodě a byla vyvinuta metoda stanovení tohoto léčiva. Ta byla úspěšně aplikována při analýze injekčního roztoku. |
cze |
dc.event |
13th ISC Modern Analytical Chemistry (20.09.2017 - 21.09.2017, Praha) |
eng |
dc.peerreviewed |
yes |
eng |
dc.publicationstatus |
postprint |
eng |
dc.relation.publisherversion |
http://web.natur.cuni.cz/analchem/isc/isc13.pdf |
|
dc.identifier.wos |
000435216500038 |
|
dc.identifier.obd |
39879476 |
eng |