Electrochemical DNA biosensors – useful diagnostic tools for the detection of damage to DNA caused by organic xenobiotics (a review)

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dc.contributor.author Vyskočil, Vlastimil
dc.contributor.author Blašková, Marta
dc.contributor.author Hájková, Andrea
dc.contributor.author Horáková, Eva
dc.contributor.author Krejčová, Zuzana
dc.contributor.author Stávková, Klára
dc.contributor.author Wang, Joseph
dc.date.accessioned 2014-10-10T06:50:07Z
dc.date.available 2014-10-10T06:50:07Z
dc.date.issued 2012
dc.identifier.isbn 978-80-7395-563-2 (printed)
dc.identifier.isbn 978-80-7395-564-9 (on-line)
dc.identifier.uri http://hdl.handle.net/10195/58381
dc.description.abstract Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between studied analytes and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review should provide evidence that the electrochemical approach brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between organic xenobiotic compounds and DNA. eng
dc.format p. 141-162 eng
dc.language.iso eng
dc.publisher Univerzita Pardubice
dc.relation.ispartof Sensing in Electroanalysis. (K. Kalcher, R. Metelka, I. Švancara, K. Vytřas; Eds.). 2012, Volume 7. eng
dc.rights open access eng
dc.subject supramolecular chemistry eng
dc.subject DNA biosensors eng
dc.subject DNA damage detection eng
dc.subject review eng
dc.title Electrochemical DNA biosensors – useful diagnostic tools for the detection of damage to DNA caused by organic xenobiotics (a review) eng
dc.type Article
dc.peerreviewed yes eng
dc.publicationstatus published eng


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