xmlui.ArtifactBrowser.SimpleSearch.filter.source:Sensing in Electroanalysis. (K. Kalcher, R. Metelka, I. Švancara, K. Vytřas; Eds.). 2012, Volume 7.
Abstract:
Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the
electrochemical investigation of interactions between studied analytes and DNA. Observing the
pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics
provides good evidence for the interaction mechanism to be elucidated. Such interaction can
also be used for sensitive determination of these compounds. This short review should provide
evidence that the electrochemical approach brings new insight into human health protection or
rational drug design and leads to further understanding of the interaction mechanism between
organic xenobiotic compounds and DNA.