The study on the properties of self-assembled bimolecular layers at the gold electrode with incorporated calixarenes for dopamine and epinephrine detection
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The study on the properties of self-assembled bimolecular layers at the gold electrode with incorporated calixarenes for dopamine and epinephrine detection
Zdrojový dokument:Sensing in electroanalysis. K. Vytřas, K. Kalcher, I. Švancara (Eds.). 2010, Volume 5.
Abstrakt:
Supported self-assembled lipid films (sBLM) on a gold electrode have
been used as support for calix[4]arene (C1) and calix[6]arene (C2). The biosensing
ability of such structures for dopamine (DA) and epinephrine (EP), was studied by
electrochemical impedance spectroscopy (EIS). We showed that calixarenes
selectively discriminate DA and EP. The sensitivity of detection by means of
capacitance changes of EP was higher for C1 in comparison with C2 and reached 30
μmol⋅L−1. DA has been detected with much lower sensitivity (approx. 100 μM) that
did not depend on the type of calixarene used. However, sensitivity of detection of
DA by means of charge transfer resistance, Rct, determined from impedance spectra
was much higher, reaching 1.0 μmol⋅L−1.