Sensors membrane electrodes for sensitive determination of hyoscine butylbromide in pharmaceutical formulation and in human plasma

Abstract

The proposed sensors of the construction of Hyoscine Butylbromide (HyB) ionselective electrodes based on the complex ion associate of hyoscine with tetraphenyl borate ionophor in the polyvinyl chloride (PVC) matrix with dioctyl phtalate and dibutyl sebathate as plasticizers. The electrochemical performance characteristics of the two HyB-selective electrodes were evaluated according to IUPAC standards. Sensors show stable potential response with near Nernstian slope of 52.42, 54.57 mV per decade for sensors denoted as № 1 and 2, respectively. Selectivity coefficients data for different organic and inorganic ions are also presented. The two sensors have fast response time (20-30s) and applicable over a wide range of the operational pH (6-10). The results obtained from the determination of HyB with the two proposed electrodes have shown the average recoveries of 98.6%, 99.6% for analysis of tablets and 100.17%, 99.01 for (spiked) human plasma. The data agree well with those obtained by the standard reference methods.