http://hdl.handle.net/10195/34542 Wed, 19 Jun 2013 17:44:22 GMT 2013-06-19T17:44:22Z http://hdl.handle.net/10195/37279 Title: New targeting system for antimycotic drugs: beta-Glucosidase sensitive Amphotericin B-star poly(ethylene glycol) conjugate Authors: Drabina, Pavel; Sedlák, Miloš; Bílková, Eliška; Šimůnek, Petr; Buchta, Vladimír Abstract: A new targeting potentially intravenous conjugate Amphotericin B (AMB)-star poly(ethylene glycol) (sPEG) (M = 25,160) has been synthesized and characterized. It contains a beta-D-glucopyranoside molecular switch which is sensitive to beta-glucosidases (E. C. 3.2.1.21). The beta-glucosidase-catalyzed release of AMB from the polymeric carrier was proved in vitro by means of spectrophotometry and HPLC. (C) 2008 Elsevier Ltd. All rights reserved. Tue, 01 Jan 2008 00:00:00 GMT http://hdl.handle.net/10195/37279 2008-01-01T00:00:00Z http://hdl.handle.net/10195/37278 Title: Fe-Catalyzed reactions of 2-chloro-1,7-dienes and allylmalonates Authors: Drabina, Pavel; Nečas, David; Sedlák, Miloš; Kotora, Martin Abstract: Fe(III)(BIAP)Cl-3 complex catalyzes alkylative cyclization of 2-chloro-1,7-heptadiene in the presence of triethylaluminum. It also catalyzes deallylation of certain 2-allyl-2-substituted malonates under the same reaction conditions. (c) 2007 Elsevier Ltd. All rights reserved. Mon, 01 Jan 2007 00:00:00 GMT http://hdl.handle.net/10195/37278 2007-01-01T00:00:00Z http://hdl.handle.net/10195/37277 Title: New Substituted Mono-and Bis(imidazolyl)pyridines and their Application in Nitroaldolisation Reaction Authors: Drabina, Pavel; Keder, Roman; Hanusek, Jiří; Sedlák, Miloš Abstract: New chiral nitrogen ligands based on the substituted mono- and bis(imidazolyl)pyridines have been prepared and characterised. Their complexes with cupric acetate were used as catalysts in the nitroaldolisation reaction. In the case of optically pure complexes of mono(imidazolyl)pyridine, the isolated products were 2-nitro-1-(2-nitrophenyl)ethanols or 2-nitro-1-(4-nitrophenyl)ethanols in overall yields of 49-93 % and with the maximum enantiomeric excess of 15.6 %. The complexes of bis(imidazolyl)pyridine also catalyse the nitroaldol reaction, the yields being 64-90 %, but with zero enantioselective excess. Sun, 01 Jan 2006 00:00:00 GMT http://hdl.handle.net/10195/37277 2006-01-01T00:00:00Z http://hdl.handle.net/10195/37276 Title: New chiral ligands and iron(III) complexes based on 2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridines Authors: Drabina, Pavel; Sedlák, Miloš; Císařová, Ivana; Růžička, Aleš; Hanusek, Jiří; Macháček, Vladimír Abstract: New ligands and their complexes with iron(III) chloride have been suggested and prepared: (R,S)-, (R,R)- and (S,S)-2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl) pyridines. Both the ligands and their complexes were characterised by 1H and 13C NMR spectroscopy, optical rotation and X-ray diffraction. Thu, 01 Jan 2004 00:00:00 GMT http://hdl.handle.net/10195/37276 2004-01-01T00:00:00Z